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Research on naturally derived modulators of melanogenesis has revealed that a diverse range of compounds can either suppress or enhance melanin synthesis through pathways such as ERK/MAPK, cAMP-PKA-CREB, and MITF-mediated transcription, offering promising avenues for the treatment of pigmentation disorders and the development of cosmetic applications
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However, calcium-activated caspase and oxidative stress both contribute to the fragmentation of the N-terminus of band 3 [150], ultimately depriving RBCs of the capacity to inhibit GAPDH (and other glycolytic enzymes) by mechanism of inhibitory binding to this region [59,60]
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