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Los primeros experimentos en animales llevados por Whipple, en la década de los años 20 del siglo XX, sobre enzimas hepáticas, enfermedad hepática y hemoglobina, demostraron que la ingesta de hígado y de sus extractos mejoraba los cuadros de anemia convencional, lo que sirvió para abrir una vía de investigación para la anemia perniciosa, todavía un gran misterio

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Although often promoted as fat-burning aids , their primary clinical application is in supporting metabolic processes , especially when integrated into supervised weight loss programs