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Post-Exertional Malaise (PEM): The upregulation of intracellular glutathione via the Nrf2 pathway helps neutralize the massive surge of reactive oxygen species generated during physical or cognitive exertion, potentially reducing the severity and duration of PEM crashes

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Hepatic DCs with high intracellular lipid content more effectively activate T cells, NK cells, and NKT cells, while those with lower lipid levels are better at promoting Treg cell-mediated immune tolerance[69]