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The pentose phosphate pathway is an anabolic alternative: it neither produces nor consumes ATP directly, focusing instead on generating NADPH for biosynthesis and ribose 5-phosphate for DNA/RNA

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The REDEFINE 1 Phase 3 trial randomized 3,417 adults with overweight or obesity (without diabetes) to semaglutide+cagrilintide 2.4/2.4 mg, semaglutide alone, cagrilintide alone, or placebo for 68 weeks