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The research rationale is that inhibiting NNMT preserves intracellular NAD+ and SAM, which in adipocyte models suppresses de novo lipogenesis
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For that reason, an untreated pernicious anemia often leads to neurological damage, which should explain why so many patients with neurological disorders such as Alzheimer, multiple sclerosis, peripheral neuropathy, and Bell’s Palsy, benefit from B12 shots
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