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NNMT knockdown significantly decreased glucose consumption and the expression of glycolysis-related enzymes, including HK2, LDHA, and PAGM1, thereby increasing the 5-FU sensitivity of EC1 cells ( PGAM1 upregulated 3-phosphoglycerate (3-PG) and 2-PG levels, inhibiting aerobic glycolysis (86)

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Osteoarthritis is the most common cause of knee pain overall, particularly in adults over 50, producing gradual stiffness, aching after rest, and pain that worsens with prolonged activity