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🔬 Hepatic Cytochrome P450 Enzyme Families: Drug Metabolism The liver plays a central role in drug metabolism, with the Cytochrome P450 (CYP450) enzyme system driving the oxidative transformation of countless medications and

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Citrulline serves as the direct precursor of arginine (ARG), an amino acid that is involved in several physiological roles including urea cycle function, protein synthesis, creatine and polyamines synthesis, ammonia detoxification, and nitric oxide (NO) synthesis [38], although its priority for utilization under different conditions remains puzzling [40]