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On the other hand, a decrease in autophagy has been reported in several neurodegenerative disorders, which proposes that this process is a factor that contributes to protein accumulation and cellular toxicity due to problems in protein folding, as in AD (Menzies et al., 2011)
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The aim of this commentary is to provide an update on this more recent evidence and to propose how our understanding of MS pathophysiology should evolve
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