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Not only are laboratory rats bred to be healthy under standard laboratory conditions, potentially reducing the genetic factors making them susceptible to disease, they are also fed an exceedingly healthy diet [2] and are often largely free of infections, environmental toxins, and other oxidative stress factors associated with ASD in humans

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We propose that CaSR may be an important nexus for the interaction of glutathione and Ca and that the lesser known of these three compounds, CySSG, may have physiological roles in regulating CaSR activity through its receptor-binding activity