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Compared to PEGylated structures, these constructs offer several potential advantages, including the ability to genetically encode their production to obviate the need for chemical conjugation, achieve more homogenous end products, and offer a large design space wherein peptide length and identity can be precisely tuned to produce desirable overall properties

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Series 2: β3-AR knock-out mice (the gene for the β3 receptor is knocked out) in the same design, to check whether β3 is necessary for the AOD-9604 effect