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whether anything similar occurs in humans is unknown Signs it's working · Laboratory markers (research) ✓Fewer SA-β-gal positive (senescent) cells [2] ✓Lower aging markers p16 and p21 [3] ✓Less DNA-damage signal (gamma-H2AX) [3] ✓Higher apoptosis signals: BAX and cleaved caspase-3 up, BCL-2 down [3] Signs it's working · Animal/physical outcomes (research) ✓Regrown fur density in aged mice [1] ✓Better kidney function [1] ✓Improved running endurance and grip strength [1] ✓Reduced artery stiffness [3] Signs it's working · What people report after a cycle ✓More energy and better recovery in the weeks following a cycle ✓Improvements in skin quality and tone ✓Better joint comfort and mobility ✓A general sense of "feeling younger" between cycles Not seeing results