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The animals were administered juice in two doses of 1.0 or 0.5 mL/rat/day, beginning one week after the final N -butyl- N -(4-hydroxybutyl)-nitrosamine treatment and continuing for six months (until the end of the study)

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The sequence was qualified by FastQC (version 0.11.7), trimmed by Trimmomatic (0.38), and mapped using the HISAT2 (version 2.1.0) program