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PMNs are then directed to the infection site through GPCR recognition of a gradient of locally produced chemoattractants and inflammatory agents, including interleukin-8 (IL-8), platelet activating factor (PAF), leukotriene B4 (LT4), complement factor C5a, and the bacterial-peptide analog, fMLP, a neutrophil chemoattractant (Migeotte et al., 2006