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Here are some other ways to reduce discomfort, if needed (Usach, 2019): Ask your healthcare provider if you can apply a topical anesthetic, like benzocaine, before injection

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EFFECT OF DISSOLUTION MEDIA ON SOLUBILIZATION OF SURFACTANTS When the formulation contains the cationic drug and an anionic surfactant and when the concentration of the surfactant is lower than the CMC in the dissolution medium, the dissolution rate of the drug may be significantly different in various pH media