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When the body detects these pathogens, the immune system launches a massive defensive response, releasing pro-inflammatory cytokines like IL-6 and TNF-α in what is sometimes called a "cytokine storm." While this inflammatory response is necessary to destroy the virus, it comes at a steep metabolic cost

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The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus