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**Morning:** While Azelaic acid can be used in the AM, retinol is generally advised for PM use because of its photosensitizing properties

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To assess the general relevance of the investigated positions in the context of alternative arGSTs, we introduced three selected substitutions (A/V12M, C13S and N108H) into the two well-studied arGSTs Ph AN9 and Vv GST4