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This intense inflammatory response disrupts the tight junctions between intestinal epithelial cells, significantly increasing intestinal mucosal permeability, resulting in the so-called “leaky gut” state (Nadella and Kanneganti, 2024)
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The effect of NAC treatment in mice is sex dependent as NAC was found to only increase lifespan in males, but not in females (Flurkey et al., 2010)
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