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Since the levels of tHcy in Tg-I278T Cbs −/− mice are comparable to those observed in the few non-transgenic Cbs −/− mice that make it into adulthood [25], this suggests that high tHcy levels may not be the direct cause of the acute liver failure and high neonatal lethality rates observed in non-transgenic Cbs −/− mice

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2 and 3 are shown in Supplementary Data 1