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In another cohort from Colombia, metformin administration significantly boosted Prevotella and Megasphaera genus, responsible for bacterial vaginosis, while reducing Clostridiaceae 02d06, Oscillospira and Barnesiellaceae ( Bacteroids and Escherichia species and negative associations were obsevered with Ruminocococus and Faecalibacterium even with shorter duration of metformin treatment in Japanese cohort (Li et al., 2021)