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First-line obesity treatments include lifestyle intervention (e.g., low-calorie diets) and behavioral modification therapies 4,5 since approved obesity medications have limited efficacy and commonly have side effects 6
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Research from Ng and colleagues (published in Molecular and Cellular Endocrinology, 1990s) identified this region as responsible for GH's lipolytic activity, separate from the receptor-binding domains at positions 1 to 175 that drive IGF-1 production and diabetogenic effects
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