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Constipation in B12 deficiency is primarily neurogenic, due to autonomic and enteric neuropathy causing slow gut motility β’ Constipation may precede anemia β’ Often improves after B12 replacement β’ Think of B12
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Similarly, during a malaria vaccine research program in 1986, WRAIR developed the adjuvant ALFQ, which consists of liposomes containing saturated phospholipids, cholesterol, monophosphoryl A and saponin QS21, which have been proven to be potent and safe [161]