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These findings suggest that microbiological dysbioses specific to sex, more precisely the increased prevalence of Lachnospiraceae in females, may account for the earlier onset and greater severity of lupus symptoms
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On the other hand, CYP3A4 was discovered as the major CYP isoform responsible for the metabolism of mitragynine with small or negligible contributions from CYP2C9, 2C19, and 2D6
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