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Based on pathological, immunohistochemical and molecular features, invasive BC has been classified into luminal A, luminal B, HER2 and triple negative A and triple negative B subtypes ( Figure 1 ) ( Figure 1 2 TNBC: molecular subtypes, therapeutic targets, and emerging treatment strategies TNBC is a heterogeneous type of BC that comprises nearly 15-20% of all diagnosed cases ( TNBC subtyping is concerned, Lehmann et al ( Around 15% of the BC patients accounting for TNBC exhibit a more aggressive clinical profile than any other cancer type