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Isolated in the 1970s on the basis of a functional observation, its association with delta-wave EEG activity during sleep, DSIP has resisted a clean receptor-and-pathway explanation in the decades since, even as research has documented effects reaching well beyond sleep into stress-response, circadian, and neuroendocrine signaling

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The SAR studies showed that α-bromocinnamaldehyde 22a , α-chlorocinnamaldehyde 22b , and α-methylcinnamaldehyde 22c compounds reduced both monophenolase and diphenolase activity on tyrosinase (Figure 8(a))