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The Cox group demonstrated the utility of combinatorial biocatalysis to generate a web-like biosynthetic network of chimeric pathways containing oxidative enzymes acting upon the aristolochene ( 484 ) core in concert (Figure 123)
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Another expanding therapeutic area involves repurposing drugs targeting Glucocerebrosidase (GCase) for Parkinson’s patients with the GBA1 beta-glucosylceramidase (GBA) mutation
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