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ASH1L consists of an AWS (associated with SET) domain, an SET domain, a cysteine-rich post-SET domain, a bromodomain (BrD), a plant homeodomain (PHD) zinc finger, and a bromo-adjacent homology (BAH) (21) ( Figure 1A )
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They bind to various proteins or enzymes as cofactors or structural components in regulating several physiological processes, such as energy metabolism, mitochondrial respiration, inflammatory responses, and antioxidants
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