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In vivo studies showed that 59 exhibited the strongest anti‐hyperuricemia and renal protective activity, effectively lowering serum uric acid levels in mice with hyperuricemia by inhibiting XO activity and also effectively reducing urate accumulation in the kidney

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A recently described example in which a glutathione S -conjugate is formed by Michael addition across a reactive double bond followed by reversible cysteine S -conjugate formation involves (6)-shogaol