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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimer’s disease (82-86)

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However, excessive or inadequate consumption can lead to certain problems: Urine discoloration: B2 (riboflavin) often gives urine a bright yellow tint