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A 24-month, double-blind RCT (N=65, mean age 79) published in the Annals of Internal Medicine found that 25 mg/day of oral MK-677 increased IGF-1 by approximately 40% and lean body mass by 1.6 kg versus placebo, though functional strength outcomes did not significantly differ [4]

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74 Jiang, D.-Q., Li, M.-X., Wang, Y