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doi: 10.1016/j.jhep.2013.12.019

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Then, in vivo blockade of Wnt signaling by inducibly expressing the secreted Wnt antagonist Dkk1 resulted in a significant degeneration of DAergic cortico-striatal excitatory synapses in striatum and a decrease in glutamate release from cortico-striatal afferents [78]