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GPX1, due to its affinity for H 2 O 2 and its abundance in most cells, is the key enzyme responsible for minimizing cytosolic H 2 O 2 levels as well as mitochondrial H 2 O 2 levels where no catalase is present in most mammalian cells [49,51,52]

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Moreover, the deletion of T-bet can partially bypass the blockade of CD103 + T RM cells formation caused by the absence of TGF-β signaling, promoting the differentiation of CD103 + T RM