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The high fatality rate of PQ poisoning is due to multiple organ dysfunction ranging from impairment in the lung, gastrointestinal tract, pancreas, kidney, liver, and heart to the brain(1, 4-6)
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Binding of CNTF to CNTFRα induces the ß-receptors gp130 and LIFrβ, which then activate signaling cascades including JAK/STAT, Ras/MAP kinase and the phosphatidylinositol 3-kinase pathway (113) ( Figures 1B, D, E )
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