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[8] These findings apply only to that mouse strain, sex, dose schedule, and study design

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A1AT has been shown to reduce in vitro apoptosis of neutrophils, by inhibiting the proteasomal degradation of the antiapoptotic protein Mcl-1 ( Again, its main effect on cells of the monocyte/macrophages lineage is anti-inflammatory and pro-tolerogenic activity: first of all, in vitro studies on human monocytes or total PBMCs (peripheral blood mononuclear cells) evidenced a reduction in the production of proinflammatory cytokines (i.e