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Following the positive REDEFINE 1 Phase 3 data (published June 2025, PMID: 40544433), Novo Nordisk announced plans to file regulatory applications for CagriSema for obesity in the United States (FDA), European Union (EMA), and other major markets in 2025–2026

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In particular, the delayed administration of this inhibitor for 5 h was more effective than NAC in AIH patients